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Both medications are glucagon-like peptide-1 (GLP-1) receptor agonists, though tirzepatide also activates GIP receptors, which may contribute to slightly stronger average weight loss results in clinical trials

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Individual responses may vary, and pre existing conditions can influence safety

Be aware that most changes need to be made at least three to five days in advance or you risk being charged for that weeks order

High-fat or heavily processed foods can stay in the stomach longer, potentially worsening the nausea caused by both metformin and semaglutide